GeneDistiller 2014

species	human	build	37 36	display online help (check this to see pop-up descriptions for each element)
order / prioritise genes		position random homozygosity score homozygosity frequency in cases gene symbol expression similarity interaction score Maestro score mitochondria prediction tissue-specific expression prioritise with self chosen parameters prioritise with focus on mitochondrial genes prioritise with focus on possible pathways (interaction and expression similarity) prioritise with focus on tissue-specific expression

output as HTML plain text (tab delimited) Microsoft Excel file
NCBI synonyms	NCBI geneRIFs ( show only the first 10 geneRIFs)
Pathways (Reactome)	Transcripts (ENSEMBL) / ExonPrimer
Protein families (ENSEMBL)	Protein domains (InterPro)
Protein domains (PFAM)	Paralogs / sequence similarity (from ENSEMBL)
Pathways (Kegg)	Human Phenotype Ontology
OMIM reports ( show full reports)	MGD phenotypes ( show detailed descriptions)
Genbank files	GeneOntology terms
STRING interactions	Maestro score / mitochondria prediction
OrphaNet

linkage interval chromosome   1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT from to bp/Mbp (NCBI Build 37) Values below 400 will be converted to Mbp. If (from) or (to) is not specified, the telomer will be used. gene symbol dbSNP ID / Affymetrix ID microsatellite type all snRNA pseudo rRNA unknown other snoRNA protein-coding tRNA miscRNA Count

single genes / gene lists HGNC gene symbols / NCBI Entrez gene IDs ENTER_YOUR_CANDIDATE_GENES Gene symbols and IDs must be comma-separated. * and % can be used as wildcards for gene symbols. whole genome analysis mitochondriome analysis    whole genome analysis    mitochondrial genes à la MitoCarta known disease genes OMIM IDs or keywords

		compare expression search for interactions
compare with these genes (Entrez gene ID / HGNC gene symbol)		(NCBI Gene ID or gene symbol; comma separated)
compare with these OMIM entries (ID or keyword)		(OMIM ID; comma separated)
limit to genes with a similar expression		cut-off value

highlight these...		show only genes...
highlight these keywords (OMIM/GeneRIFs)		with at least one of these words in their OMIM reports
highlight these HPO IDs (and their subclasses)		to which at least one of these HPO IDs applies
highlight these MGD phenotypes	pigmentation phenotype tumorigenesis normal phenotype no phenotypic analysis nervous system phenotype renal/urinary system phenotype muscle phenotype liver/biliary system phenotype limbs/digits/tail phenotype life span-post-weaning/aging lethality-postnatal lethality-embryonic/perinatal adipose tissue phenotype homeostasis/metabolism phenotype hearing/vestibular/ear phenotype growth/size phenotype endocrine/exocrine gland phenotype embryogenesis phenotype digestive/alimentary phenotype craniofacial phenotype cellular phenotype cardiovascular system phenotype behaviour/neurological phenotype immune system phenotype respiratory system phenotype reproductive system phenotype skeleton phenotype vision/eye phenotype touch/vibrissae phenotype skin/coat/nails phenotype taste/olfaction phenotype other phenotype haematopoietic system phenotype	to which at least one of these phenotypes was assigned
highlight these GO IDs (and their subclasses)		to which at least one of these GO IDs applies
highlight these Kegg pathways (specified by number)		involved in at least one of these Kegg pathways

highlight homozygosity frequencies in cases >= Tick 'set cookie' in the upper right corner of the page to store your settings.

Select the analysis you wat to check for genes homozygous in regions and set filtering criteria
	analysis	Tutorial: tutorial
	highlight homozygosity scores >=	x maximum score (0..1)	show only genes fulfilling the criterium
	(0..1)	show only genes fulfilling the criterium